How to update SQLite database from DataGridView in Visual Basic 2013 .net?

I am displaying data from SQLite table into a DataGridView as following -

Private Sub Subjects_Manager_Load(sender As Object, e As EventArgs) Handles MyBase.Load
        con = New SQLiteConnection("Data Source = c:\demo\test.db;Version=3;")
        con.Open()
        sql = "SELECT * FROM med_subjects"
        da = New SQLiteDataAdapter(sql, con)
        da.Fill(ds, "SubjectsList")
        DataGridView1.DataSource = ds.Tables("SubjectsList").DefaultView
        With DataGridView1
            .RowHeadersVisible = False
            .Columns(0).HeaderCell.Value = "Subject Id"
            .Columns(1).HeaderCell.Value = "Subject Name"
        End With
        DataGridView1.Sort(DataGridView1.Columns(0), System.ComponentModel.ListSortDirection.Ascending)
        con.close()
End Sub

I want to save changes done in DataGridView (either Updation of Row/s or Insertion of Row/s) back to SQLite table. But I couldn't find a way to do so.