Is there any difference between these two code? 'Insert three variable to a table at once' & 'Insert the 3rd variable by UPDATE ... WHERE...'

I'd like to know, if there are some Situation that These two Kinds Code will have different results?

The 1st:

cur.execute('''INSERT OR REPLACE INTO Member
    (user_id, course_id) VALUES ( ?, ? )''', 
    ( user_id, course_id ) )

cur.execute('''UPDATE Member SET role = ? 
    WHERE user_id = ? AND course_id = ?''', 
    (role, user_id, course_id))

The 2nd:

cur.execute('''INSERT OR REPLACE INTO Member
    (user_id, course_id, role ) VALUES ( ?, ?, ? )''', 
    ( user_id, course_id, role ) )

Here is the Definition of this table：

CREATE TABLE Member (
    user_id     INTEGER,
    course_id   INTEGER,
    role        INTEGER,
    PRIMARY KEY (user_id, course_id)
)