Most space efficient way to store 200 million records?

I have this type of record:

1. name varchar(128)
2. description varchar(64)
3. field varchar(32)

Combination of (name, description) needs to be unique and name needs to be indexed for fast search/retrieval. Updates are infrequent, but large for example I might add 1 million records at a time, but there plenty of reads throughout the day.

I have over 200 million records like these, possibly becoming 300 in the future, when I tried adding it to MySQL, DB has grown huge I'm looking at 200GB+ with all the indices and etc. Is there a space efficient way to structure this data. Any DB tech is fine with me, as long it does not need lots of ram and uses less disk.

Thanks, in advance!